Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism.

ABSTRACT: Autism spectrum disorder is a complex neurodevelopmental disease characterized by altered cortical network excitability. Recent genetic studies have identified deep layer V cortical pyramidal neurons in the frontal cortex as central to autism pathophysiology, yet the cortical circuits, plasticity mechanisms and molecular signalling pathways involved remain poorly understood. Layer V pyramidal neurons consist of two main types with distinct functional roles: intratelencephalic neurons, which respond to low-frequency stimulation and project within the cortex and striatum, and pyramidal tract neurons, which are tuned to theta-frequency inputs and convey information to subcortical structures. Determining which of these two neuron types is more critical to autism pathophysiology and whether dis

SUBMITTER: Vitale C 

PROVIDER: S-EPMC12493053 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature