Cell-type-specific networks during hippocampal seizures at the micro- and macroscale.

ABSTRACT: Epilepsy is a network disorder, involving neural circuits at both the micro- and macroscales. While local excitatory-inhibitory imbalances are recognized as hallmarks at the microscale, the dynamic roles of distinct neuron types during seizures remain poorly understood. At the macroscale, interactions between key nodes within the epileptic network, such as the central median thalamic nucleus (CMT), are critical to the hippocampal epileptic process. However, the precise mechanisms underlying these interactions remain unclear. In this study, we investigated the microcircuit dynamics within the seizure onset zone and secondary spreading regions, along with the network connectivity between the hippocampus and CMT, using a 4-aminopyridine (4-AP)-induced hippocampal seizure model. Rats were allo

SUBMITTER: Wang J 

PROVIDER: S-EPMC12493063 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature