Characterization and Application of Novel Exercise Recovery Patterns That Reflect Cardiac Performance: A Substudy of the SEQUOIA-HCM Trial.

ABSTRACT:

Background

Post-exercise oxygen uptake recovery (VO₂Rec) is slow in advanced heart failure. We sought to establish easily derived VO₂Rec measures and evaluate their cardiospecificity and prognostic relevance in patients with dyspnea on exertion. We further sought to determine VO₂Rec modifiability proportional to changes in cardiac function with disease-specific treatment of obstructive hypertrophic cardiomyopathy.

Methods

VO₂Rec patterns were evaluated in relation to cardiac performance and the primary outcome of heart failure hospitalization or death in a referral cohort with dyspnea on exertion undergoing cardiopulmonary exercise testing with hemodynamic monitoring (MGH-ExS [Massachusetts General Hospital Exercise Study]). We the

SUBMITTER: Campain J 

PROVIDER: S-EPMC12493091 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature