Psychotic-like experiences in adolescents enriched for high-risk for developing severe mental illness: change over two-years and associations with neural reward processing and affective symptoms.

ABSTRACT: Psychotic-like experiences (PLEs) -subclinical experiences or symptoms that resemble psychosis, such as hallucinations and delusional thoughts-often emerge during adolescence and are predictive of serious psychopathology. Understanding PLEs during adolescence is crucial due to co-occurring developmental changes in neural reward systems that heighten the risk for psychotic-related and affective psychopathology, especially in those with a family history of severe mental illness (SMI). We examined associations among PLEs, clinical symptoms, and neural reward function during this critical developmental period. Over two-years, 117 adolescents (aged 13-19 years at baseline) at high-risk (n = 74) or low-risk (n = 43) for SMI based on family history of affective or psychotic disorder completed sym

SUBMITTER: Dong X 

PROVIDER: S-EPMC12493122 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature