Cgm1 is a β-galactoside α-(1 → 4)-mannosyltransferase involved in the biosynthesis of capsular glucuronoxylomannogalactan in Cryptococcus neoformans.

ABSTRACT: Capsular polysaccharides are present in the outermost layer of the cell wall of Cryptococcus neoformans. The capsule consists of glucuronoxylomannan and glucuronoxylomannogalactan (GXMGal), both of which are major virulence factors that enable immune evasion. This study aimed to identify a novel glycosyltransferase involved in the biosynthesis of capsular polysaccharides in C. neoformans. While glucuronoxylomannan is the predominant capsule component and plays a broad role in immune evasion, GXMGal, despite its lower abundance, is thought to contribute to pathogenicity through its structurally unique galactomannan side chain. Glycosyltransferases involved in GXMGal biosynthesis have attracted much attention as potential targets for antifungal drug development because of their role in patho

SUBMITTER: Kadooka C 

PROVIDER: S-EPMC12493134 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature