Annexin A2 interferes with complement regulation within the glomerulus.

ABSTRACT: The alternative pathway of complement is an important pathogenic driver of a variety of glomerular diseases. Factor H is a soluble complement regulatory protein, and it is known to play a critical role in protecting the kidney from alternative pathway-mediated injury. Other proteins, however, can interfere with complement regulation by Factor H, thereby predisposing the kidney to injury. Annexin A2 was previously shown to bind to Factor H and is expressed by several resident cell types in the kidney. In the current study, we show that extracellular annexin A2 binds to the region of Factor H encompassing short consensus repeats 6 to 8, impairing the ability of Factor H to regulate complement activation on the surface of glomerular endothelial cells and podocytes in vitro and in vivo. Annexi

SUBMITTER: Renner B 

PROVIDER: S-EPMC12493207 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature