Identification and verification of prognostic genes related to zinc homeostasis and zinc transport in breast cancer.

ABSTRACT:

Purpose

Zinc homeostasis and zinc transporter (ZHT) have been closely associated with the development of various cancers. Therefore, in this study, prognostic genes and their mechanisms related to ZHT in breast cancer (BC) were explored.

Patients and methods

Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were utilized to identify genes associated with Zinc homeostasis and Zinc transporter-related genes (ZHTGs) in BC. Subsequently, independent prognostic factors and their correlations with clinical features were examined to investigate their association with the prognosis of BC. Finally, we further explored the pathways and immune cells associated with BC prognosis. We also verified gene expression in tissues and cells by quantitativ

SUBMITTER: Li M 

PROVIDER: S-EPMC12493714 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature