Abnormal O-glycan sialylation in the mPFC contributes to depressive-like behaviors in male mice.

ABSTRACT: Depression presents challenges in understanding its biological basis and developing effective treatments. Posttranslational modifications provide critical insights into molecular mechanisms of disorders, yet their role in depression remains underexplored. Glycosylation has been particularly difficult to study due to its heterogeneous nature and analytical challenges, despite its potential to uncover previously unknown mechanisms. In this study, we demonstrate how chronic stress alters region-specific O-glycosylation across multiple brain regions, with a particular focus on the prefrontal cortex (PFC). Our findings reveal significant changes in sialylated O-glycosylation patterns mediated by St3gal1, a sialyltransferase essential for O-glycosylation. Notably, knockdown of St3gal1<

SUBMITTER: Seo Y 

PROVIDER: S-EPMC12494006 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature