Neonatal regulatory T cells persist into adulthood across multiple tissues with high enrichment in the skin.

ABSTRACT: Foxp3⁺ regulatory T cells (T_regs) reside in both lymphoid and nonlymphoid organs, where they play a crucial role in immune tolerance and tissue homeostasis. In mice, T_regs begin colonizing these tissues shortly after birth, contributing to long-term immune response regulation therein. However, the kinetics of T_reg generation across different tissues remains unclear. Here, we investigate T_reg ontogeny from birth to adulthood in various tissues. In lymphoid organs, the adult T_reg pool is continuously replenished with cells generated at different ages. In contrast, the skin retains a large fraction of T_regs that colonize the tissue during the neonatal period, with minimal turnover in adulthood. The liver, lungs, and

SUBMITTER: Hilaire M 

PROVIDER: S-EPMC12494032 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature