Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail.

ABSTRACT: While archaeal viruses show a stunning diversity of morphologies, many bear a notable resemblance to tailed bacterial phages. This raises fundamental questions: Do all tailed viruses share a common origin and do they infect their hosts in similar ways? Answering these questions requires high-resolution structural insights, yet no complete atomic models of archaeal viruses have been available. Here, we present the near-atomic resolution structure of Haloferax tailed virus 1 (HFTV1), an archaeal virus thriving in extreme salinity. Using cryo-electron microscopy, we resolve the architecture and assembly of all structural proteins and capture conformational transitions associated with DNA ejection. Our data reveal genome spooling within the capsid and identify putative receptor-binding and cat

SUBMITTER: Zhang DX 

PROVIDER: S-EPMC12494034 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature