Plasma Ammonia Levels Over the Course of a Hospitalisation for Overt Hepatic Encephalopathy.

ABSTRACT:

Background & aims

The role of ammonia in the assessment of Overt Hepatic Encephalopathy (OHE) remains debated. The aim of the present study was to assess the time course of ammonia levels in relation to the severity and duration of an episode of OHE requiring hospitalisation.

Methods

104 patients discharged between January 2021 and July 2024 with a diagnosis of OHE were included [80 males, 72 ± 11 years]. Clinical and laboratory indices, including ammonia levels prior to/during/after the hospitalisation, were recorded, along with the duration of the hospitalisation, precipitants, ammonia-lowering and psychoactive treatment, where applicable.

Results

Over the studied time frame, 58 (56%) patients had single OHE hospitalisations, while 20 (19%) had 2-7 OHE hospitalisati

SUBMITTER: Erminelli D 

PROVIDER: S-EPMC12494124 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature