Studying intrapulmonary pharmacokinetics for tuberculosis treatment: a systematic review of methodology.

ABSTRACT:

Objectives

Drug concentrations at the site of disease in pulmonary tuberculosis (TB) remain limitedly available, while adequate exposures of anti-TB drugs in the lungs are required for sterilization of lesions. Intrapulmonary concentration data could benefit TB treatment optimization. We conducted a systematic review to identify methods that can be used for sampling, quantifying, describing and predicting intrapulmonary pharmacokinetics of anti-TB drugs in humans.

Methods

Two systematic search strategies were conducted in databases Embase and PubMed, last searched on 18 July 2024. In total, 253 studies were identified, and their applied methods were classified into three different categories: (i) sampling techniques, (ii) quantitative analysis and (iii) modelling methods. Al

SUBMITTER: van der Feltz I 

PROVIDER: S-EPMC12494137 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature