Sex differences of synaptic plasticity and microglial remodeling in the dorsal hippocampus following trigeminal nerve injury in mice.

ABSTRACT: Peripheral nerve injury patients have chronic pain as well as poor memory and cognitive functioning that is associated with hippocampal abnormalities. Despite sex-dependent changes in the hippocampus of patients with chronic pain, detailed sex differences in hippocampal plasticity after peripheral nerve injury are not well known. In mice with infraorbital nerve chronic constriction injury (ION-CCI), we found complex sex differences in the dorsal hippocampus (dHC). ION-CCI suppressed population spikes amplitude and long-term potentiation (LTP) in the dHC compared to sham group, which was consistent in females but not males. The field excitatory postsynaptic potential was comparable between sexes in the sham group, and ION-CCI suppressed it in both sexes. Short-term facilitation after paired

SUBMITTER: Tiwari MN 

PROVIDER: S-EPMC12494171 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature