Hemin-Coated Nanoparticles as Drug Delivery Vehicles for Chemotherapeutic Agents in Cancer Therapy.

ABSTRACT: Chemotherapy holds a prominent position in contemporary cancer treatment modalities; however, poor water solubility, rapid clearance, and unintended side effects remain significant challenges. To mitigate these issues, various nanoparticle-based delivery systems have been devised to improve the pharmacokinetic and pharmacodynamic profiles of chemotherapeutic drugs. While biocompatible, most of these drug delivery systems include materials that are foreign to the human body. Consequently, it is critical for these materials to be effectively removed from the body to prevent potential toxicity. In this study, we introduce a nanoparticle-based system that utilizes only hemin, which is naturally found in the body, as an amphiphilic coating agent to facilitate the solubilization of hydrophobic d

SUBMITTER: Feng K 

PROVIDER: S-EPMC12494173 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature