MRI-based patient-specific nomogram for diagnostic risk stratification of patients with early knee OA.

ABSTRACT:

Objectives

This study is to develop a risk stratification nomogram for early-stage OA based on MRI, especially with potential sequences of MRI called T1rho and T2 mapping.

Methods

Cartilages diagnosed with early-stage OA or normal were collected and allocated into training or validation cohorts after the MRI. Eleven predictors were determined as candidate predictors for OA-anatomical signature-nomogram (OA-ASN). The performance of OA-ASN was evaluated using the concordance index (C-index), the area under the receiver operating characteristic curve (AUC), calibration plots, decision curve analysis (DCA) and clinical impact curve (CIC).

Results

A total of 199 patients were evaluated. Of these, 79 (39.7%) had early OA. Infrapatellar fat pad (IPFP), T1 rho and T2 mapping

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12494199 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature