Association of serum intestinal fatty-acid binding protein, inflammatory and oxidative stress markers with colorectal cancer among Ghanaian patients.

ABSTRACT:

Background

In sub-Saharan Africa, colorectal cancer (CRC) is becoming an increasingly serious public health issue. However, little is known about the relationships between inflammation, oxidative stress, and intestinal barrier biomarkers in African populations. This study examined the association between selected biomarkers, dietary factors, and the risk of CRC among treatment-naïve patients in Ghana.

Methods

This hospital-based analytical cross-sectional study included twenty-eight CRC patients and twenty-six non-CRC volunteers. Serum samples processed from whole blood were analyzed for tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and intestinal fatty acid binding protein (iFABP) levels using enzyme-linked immunosorbent assays (ELISA). The thiobarbituric acid te

SUBMITTER: Kwao-Zigah G 

PROVIDER: S-EPMC12494277 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature