Revealing the molecular mechanisms underlying Xuebijing against sepsis and septic acute kidney injury via bioinformatics and experimental approaches.

ABSTRACT:

Background

Sepsis and its related complication acute kidney injury (septic-AKI) are associated with high mortality and morbidity, and have become a global health challenge. Xuebijing (XBJ) injection prepared from five traditional Chinese medicines (TCM) is commonly used for clinical treatment of sepsis and septic-AKI. Yet, the underlying therapeutic mechanism of XBJ is remain elusive. This study aims to unveil the underlying mechanisms of XBJ in treating sepsis and septic-AKI.

Methods

In this study, we used network pharmacology and molecular docking to screen the core drug-disease targets and predict the potential mechanism involving in XBJ against sepsis and septic AKI. Furthermore, in vitro experiments were performed to verify the predicted results and clarify the underlyi

SUBMITTER: Li X 

PROVIDER: S-EPMC12494294 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature