Modeling neuron-astrocyte interactions in neural networks using distributed simulation.

ABSTRACT: Astrocytes engage in local interactions with neurons, synapses, other glial cell types, and the vasculature through intricate cellular and molecular processes, playing an important role in brain information processing, plasticity, cognition, and behavior. This study advances understanding of local interactions and self-organization of neuron-astrocyte networks and contributes to the broader investigation of their potential relationship with global activity regimes and overall brain function. We present six new contributions: (1) the development of a new model-building framework for neuron-astrocyte networks, (2) the introduction of connectivity concepts for tripartite neuron-astrocyte interactions in biological neural networks, (3) the design of a scalable architecture capable of simulatin

SUBMITTER: Jiang HJ 

PROVIDER: S-EPMC12494295 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature