Induction of lipid A modification genes in <i>Pseudomonas aeruginosa</i> cells tolerant to a commercially available contact lens disinfection solution.

ABSTRACT: Introduction. Pseudomonas aeruginosa has a high propensity to develop drug resistance and is a leading cause of bacterial keratitis, particularly amongst contact lens (CL) wearers. Although CL wearers are advised to regularly disinfect their CLs with fresh multi-purpose disinfection solutions, adherence is often poor. This raises the possibility that P. aeruginosa may develop resistance to multi-purpose disinfection solutions when exposed to sub-inhibitory concentrations of disinfection solutions.Aim. We therefore investigated the survivability of a CL-associated keratitis isolate of P. aeruginosa (PA76203) in a commercially available multi-purpose disinfection solution (Opti-Free RepleniSH) when pre-treated with a sub-inhibitory concentration of solution

SUBMITTER: Hilliam Y 

PROVIDER: S-EPMC12494483 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature