Emerging role of HIC1 in prostate cancer progression and therapeutic response: A novel perspective.

ABSTRACT: Prostate cancer (PCa) is a leading cause of cancer-related death in men, with its progression and treatment response being complex. The study focuses on the role of HIC1 (Hypermethylated in cancer 1) in PCa, revealing its downregulation in PCa tissues compared to normal counterparts. Using transcriptome sequencing and bioinformatics, it was found that HIC1 influences key cellular processes like cell growth, proliferation, invasion, and androgen receptor (AR) signaling in PCa. Specifically, AR was identified as a transcription factor for insulin receptor substrate 2 (IRS2), which activates the PI3K/AKT pathway, enhancing PCa cell proliferation and invasion. However, this effect could be reversed by IRS2 inhibition using NT157. Furthermore, HIC1 overexpression reduced castration resistance i

SUBMITTER: Xue D 

PROVIDER: S-EPMC12494493 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature