Alteplase treatment in patients with minor ischemic stroke: a nationwide registry analysis.

ABSTRACT:

Background

Controversy persists regarding the definition of disabling minor stroke and which patients with minor strokes may still benefit from thrombolysis. This study aimed to identify which patients with minor ischemic stroke may benefit from alteplase in a large national registry.

Methods

This prospective cohort study utilized data from the Third China National Stroke Registry (CNSR-III), covering the period from August 2015 to March 2018. Participants were divided into alteplase-treated and standard medical treatment groups. Exploratory subgroup analyses were conducted across different NIHSS scores, NIHSS subitems, and TOAST subtypes. Disabling minor ischemic stroke was defined as minor stroke (NIHSS score ≤5) with consciousness impairment, motor deficits, limb ataxia o

SUBMITTER: Yin JF 

PROVIDER: S-EPMC12494593 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature