The Metaplastic Conundrum: A National Cancer Database Analysis of Metaplastic versus Triple-Negative Ductal Breast Cancer.

ABSTRACT:

Background

Historically, treatment approaches for metaplastic breast cancer (MpBC) have mirrored that of triple-negative ductal breast cancer (TN-IDC), yet MpBC has persistently worse survival. This study describes rates and response to neoadjuvant systemic therapy (NAC) for MpBC and evaluates survival between triple-negative MpBC (TN-MpBC), biomarker-positive MpBC (nTN-MpBC), and TN-IDC by treatment approach.

Methods

The National Cancer Database was queried for females diagnosed with clinically non-metastatic MpBC or TN-IDC from 2011 to 2021. One-to-one propensity score matching between TN-MpBC and TN-IDC patients was performed.

Results

Of 5575 MpBC patients, surgery and chemotherapy rates were high. For patients who received systemic therapy and surgery, an adjuvant

SUBMITTER: Pratt CG 

PROVIDER: S-EPMC12494619 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature