Correlation of autoantibody profiles with clinical parameters in exfoliative glaucoma patients.

ABSTRACT:

Background

Exfoliative glaucoma (XFG) is characterized by elevated intraocular pressure (IOP) caused by fibrous deposits obstructing aqueous humor drainage, traditionally emphasizing mechanical factors. In this study, we aim to investigate the relationships between clinical parameters and autoimmune activity in exfoliative glaucoma (XFG) patients, and identify patterns of autoantibody reactivity among patient subgroups with differing levels of overall autoimmune activity.

Methods

We analyzed serum autoantibody profiles against 92 antigens in 116 XFG patients using an xMAP suspension bead array. Spearman correlation analysis and PERMANOVA were applied to evaluate relationships between autoantibody reactivity and clinical parameters in glaucoma management. Hierarchical cluster

SUBMITTER: Potter R 

PROVIDER: S-EPMC12494623 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature