Proteome-Wide Mendelian Randomisation Study of Adverse Perinatal Outcomes.

ABSTRACT: Despite significant advances in pre- and postnatal care over the last century, adverse pregnancy related events still occur frequently. We used Mendelian randomisation (MR) to investigate potential causal effects of the mother's and fetal blood proteome on pregnancy related outcomes including birthweight, placental weight, preeclampsia, and sporadic miscarriage. We generated a list of genetic instruments to act as proxies for plasma proteins by combining two recent large protein GWAS (4719 proteins N = 35,559 individuals; 4775 proteins N = 10,708 individuals). We identified 1724 proteins with valid cis-pQTLs for use as genetic instruments. We identified evidence for causal relationships (MR Bonferroni corrected p_Bonferroni < 2.90 × 10^-5) involving fetal effects and/or

SUBMITTER: Daubney ER 

PROVIDER: S-EPMC12494647 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature