Increased reactive astrocytes in hippocampal CA1 region mediated by decreased CXCR7 is involved in postoperative cognitive dysfunction in aged mice.

ABSTRACT: Postoperative cognitive dysfunction (POCD) is a prevalent neurological complication that significantly impairs recovery in elderly surgical patients. While astrocyte activation has been implicated in various neurodegenerative disorders, its dynamic changes and precise role in POCD pathogenesis remain poorly understood. In this study, we observed selective activation of astrocytes (but not microglia) in the hippocampal CA1 region of POCD model mice at postoperative day 3, accompanied by marked downregulation of the atypical chemokine receptor CXCR7. Notably, both astrocyte-specific CXCR7 overexpression in the hippocampal CA1 region and systemic administration of the CXCR7 agonist AMD3100 effectively attenuated astrocyte activation, reduced neuroinflammation, and significantly improved synap

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12494674 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature