Hydrogel dressing containing natural extracts inhibits dual-species biofilms of Staphylococcus aureus and Acinetobacter baumannii in ex vivo wound infection models.

ABSTRACT: Wound infections represent a significant cause of delayed wound healing. An active wound dressing was developed by incorporating extracts of Rhodomyrtus tomentosa leaf and Quercus infectoria gall in a carboxymethyl cellulose hydrogel (RQ hydrogel). In a modified artificial wound bed mimicking chronic wound infections, RQ hydrogel could inhibit up to 7 log CFU/mL of pathogens in both single- and dual-species biofilms. Antibacterial efficacy was further assessed in three different ex vivo porcine skin wound infection models. Model I: Ex vivo skin infection, the skin was exposed to dual cutures of Staphylococcus aureus/Acinetobacter baumannii. Topical application of RQ hydrogel resulted in 5 log CFU/mL reduction within 6 h. Model II: Ex vivo burn wound infection, more than 3 log CFU/mL of dua

SUBMITTER: Lethongkam S 

PROVIDER: S-EPMC12494708 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature