The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.

ABSTRACT: Changes in task-evoked activity in the entorhinal cortex (EC) and hippocampus have been shown to track changes in temporal context at short and long timescales. However, whether spontaneous changes in EC and hippocampal neural signals-in the absence of task demands-likewise reflect the passage of time remains unknown. Here, we leveraged a dense-sampling study in which two individuals underwent daily resting-state fMRI for 30 days. Similarity in EC- and anterior hippocampal-whole-brain resting connectivity patterns was negatively correlated with the time interval between sessions, suggesting a spontaneous, slow-drifting neural signature of time. These changes could not be explained by other time-varying factors (including session-wise changes in mood, hormones, or motion). Hippocampal conne

SUBMITTER: Wang J 

PROVIDER: S-EPMC12494713 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature