GC-MS/MS analysis of seminal plasma PUFAs in distinct subgroups of infertile men: diagnostic potential and insight into mechanisms of male infertility.

ABSTRACT: Infertility affects approximately 17.5% of the adult population, with the male factor contributing to nearly half of the cases. Seminal plasma has emerged as a potential source of biomarkers and insights into the mechanisms of male infertility; however, the significance of polyunsaturated fatty acids (PUFAs) in this body fluid remains insufficiently explored. The main objectives of the present observational study were to compare selected PUFA (linoleic acid (LA), α-linolenic acid (ALA), γ-linolenic acid (GLA), arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)) concentrations and ratios in seminal plasma between fertile (n = 22, aged 21-47) and infertile (n = 250, aged 24-45) men, as well as within infertile subgroups, including idiopathic, to investigate th

SUBMITTER: Rodak K 

PROVIDER: S-EPMC12494725 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature