A long-term self-driven metronomic photodynamic system for cancer therapy.

ABSTRACT: Metronomic photodynamic therapy is a long-term, low-dose treatment strategy that employs optical devices with continuous photosensitizer administration and requires stable device attachment with a consistent power source. These factors significantly limit patient mobility. Currently, no metronomic photodynamic therapy modality can operate independent of external devices, underscoring the critical need for in vivo light sources that function without external energy inputs. In this study, we integrate self-luminous bacteria with a photosensitizer in alginate microcapsules to create a self-driven metronomic photodynamic therapy that can be securely implanted within a tumour, thereby enabling continuous light emission without requiring an external energy source or ongoing replenishment of phot

SUBMITTER: Wang W 

PROVIDER: S-EPMC12494783 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature