Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits.

ABSTRACT: Antidepressants are among the most-prescribed drugs worldwide, and selective serotonin reuptake inhibitors (SSRIs) are among the most prescribed antidepressants, most commonly used for major depression. We sought to increase our understanding of the biological relationships between SSRI use and a range of psychiatric traits by conducting a genome-wide association study (GWAS) in two large datasets, the UK Biobank (UKB) and the US Million Veteran Program (MVP). GWAS was conducted across 22 autosomes and the X chromosome in 777,952 individuals of European ancestry (191,800 SSRI users, 586,152 control individuals) and 112,526 individuals of African ancestry (53,499 SSRI users, 59,027 control individuals). We identified 40 genome-wide significant (GWS) loci, including two on the X chromosome.

SUBMITTER: Levey D 

PROVIDER: S-EPMC12494825 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature