Effect of age on ISTH-BAT scores and low VWF diagnosis in the Zimmerman Program.

ABSTRACT:

Abstract

An essential component of low von Willebrand factor (VWF)/type 1 von Willebrand disease (VWD) diagnosis is to identify patients with an increased bleeding phenotype, as most individuals with VWF levels in the 30 to 50 IU/dL range do not bleed. The International Society on Thrombosis and Haemostasis-bleeding assessment tool (ISTH-BAT), widely used for assessing bleeding severity, has recently been shown to be age dependent. Although age may also influence ISTH-BAT scores in individuals with VWF levels between 30 and 50 IU/dL, and subsequently affect low VWF diagnosis, this relationship has not been investigated. Therefore, we analyzed 325 participants from the Zimmerman Program, of whom 220 (67.7%) had abnormal ISTH-BAT scores, whereas 105 (32.3%) had normal scores. Our ana

SUBMITTER: Atiq F 

PROVIDER: S-EPMC12494827 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature