Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.

ABSTRACT:

Background

Patients with chronic obstructive pulmonary disease (COPD) are at an increased risk of severe complications and death from community-acquired pneumonia such as Streptococcus pneumoniae. Previous studies suggest that acute infection heightens the short-term risk of cardiovascular events.

Objectives

This study investigates the risk of major adverse cardiovascular events (MACE) during the acute phase of S pneumoniae infection in patients with COPD.

Methods

We conducted a self-controlled case series study in patients with COPD and a positive lower respiratory tract or blood culture for S pneumoniae between 2010 and 2017 using Danish Nationwide register data. The primary outcome was incidence of MACE and the risk interval was defined as the first 14 days after a

SUBMITTER: Riisberg NM 

PROVIDER: S-EPMC12494828 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature