Pigmentary Maculopathy in Patients with Interstitial Cystitis: Association with Pentosan Polysulfate and Other Therapies.

ABSTRACT:

Purpose

To examine the association between the development of pigmentary maculopathy and exposure to pentosan polysulfate sodium (PPS) and other therapies in patients with interstitial cystitis (IC).

Design

Single-center retrospective study.

Subjects

Patients diagnosed with IC who had ≥2 eye examinations at Wake Forest School of Medicine between January 2011 and August 2021.

Methods

Two masked retina specialists evaluated available multimodal imaging for pigmentary maculopathy using the established criteria, with any disagreements adjudicated by a third reviewer. Cases were categorized by severity and analyzed for associations with medication exposure.

Main outcome measures

Association between the development of pigmentary maculopathy with PPS exposure d

SUBMITTER: Qin S 

PROVIDER: S-EPMC12494829 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature