Discovery of new pyridine 3-carboxylic acid-based pharmacophores as dual anti-inflammatory and anti-hyperglycemic agents.

ABSTRACT: Novel nicotinic acid derivatives were synthesized as potent anti-diabetic agents. The developed inhibitors were investigated for their pharmacological in vitro screening, such as anti-diabetic, anti-inflammation, and in silico analysis. It has good interactions with α-amylase protein, with a range of -7.18 to -5.55 kcal/mol. The inhibitors were synthesized by employing the Steglich-type reaction to couple alcohol and amine derivatives. These molecules were characterized using NMR, FT-IR, and Mass spectrometry techniques. Anti-hyperglycemic activity has been screened using α-amylase protein, and the half-maximal inhibition efficiency (IC₅₀) value was evaluated, ranging from 1.324 ± 0.17 to 1.516 ± 0.14 µg. The positive control (acarbose) range is 1.273 ± 0.12 µg. Induced human RB

SUBMITTER: Ramakrishnan K 

PROVIDER: S-EPMC12494831 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature