Comprehensive bioinformatics analysis reveals prognostic significance and immunological roles of WNT gene family in breast cancer.

ABSTRACT: Breast cancer (BRCA) is one of the most commonly diagnosed cancers and the leading cause of cancer-related deaths among women worldwide. Previous studies have shown that the WNT (wingless type) gene family plays a role in the development of various cancers. However, comprehensive analysis of WNTs in BRCA remains largely unexplored. In this study, we examined the expression patterns, clinical relevance, and survival outcomes associated with the WNT family and identified key prognostic WNTs. We further investigated genetic alterations, DNA methylation, and drug sensitivity using cBioPortal, SMART, and GSCA databases. Data from GEO and DepMap were used for validation. Our findings revealed that while WNT2 and WNT7B were significantly upregulated and WNT11 was downregulated, WNT2 paradoxically

SUBMITTER: Fariha FTJ 

PROVIDER: S-EPMC12494856 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature