Sequential drug-release microsphere system for scarless wound healing.

ABSTRACT: The dynamic imbalance in skin wound healing is a key factor of hypertrophic scar (HS) formation. Traditional treatments often target only a certain stage of the wound healing process and fail to comprehensively address the dynamic imbalance, thus making it difficult to achieve scarless wound healing. This study developed a chronologically adaptive methacrylylated gelatin (GelMA)-based microsphere delivery system (G/E/T) that achieves comprehensive intervention in wound healing process through precisely orchestrated sequential release of epigallocatechin gallate (EGCG) and triamcinolone acetonide (TA). In vitro studies have confirmed that the G/E/T microsphere system, utilizing this sequential release mechanism, not only alleviates oxidative stress and inflammatory responses in the early st

SUBMITTER: Luo D 

PROVIDER: S-EPMC12494857 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature