Fermented pickles improve gut microbiota and immune profile in women in a community trial in rural Pakistan.

ABSTRACT: A gut microbiome-targeted diet can potentially mitigate chronic diseases, including malnutrition. In a prospective 12-week intervention trial, we evaluated the effects of six different plant-based fermented pickles (~ 50 g/day) on clinical, inflammatory, and gut microbiota parameters in a cohort of women (n = 230) in a rural setting with a high prevalence of undernutrition. Blood was collected at two, whereas stool was collected at three timepoints. Among fecal biomarkers, myeloperoxidase (MPO), Lipocalin-2 (LCN2), and 16S rRNA gene sequencing were measured at baseline, 8^th, and 12^th weeks. Overall, the compliance rate was > 70%. Among radish group, WBCs (p = 0.002, two-tailed paired T-test) decreased, whereas neutrophils and platelets decreased among both radish (p =

SUBMITTER: Hafeez SH 

PROVIDER: S-EPMC12494867 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature