Dynamics of detergent-resistant membranes of Plasmodium falciparum during blood stage development.

ABSTRACT: Membrane microdomains, also known as detergent-resistant membranes (DRMs), are tightly packed assemblies enriched in cholesterol and sphingolipids, where various membrane-associated processes occur. Many intracellular pathogens, including Plasmodium, exploit these raft-like structures to recognize and invade host cells. In particular, Plasmodium depends on host cholesterol to build its own membranes, as it is unable to perform sterol synthesis. Using quantitative proteomics, lipid analysis, and bioinformatics, this study defines the composition and dynamics of Plasmodium falciparum DRMs from key developmental stages: schizonts, which give rise to invasive merozoites, and gametocytes, which are responsible for transmission to the mosquito vector. Comparative analysis of the flotation proper

SUBMITTER: Sferra G 

PROVIDER: S-EPMC12494905 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature