Extended antibiotic exposure and exacerbations, mortality, and healthcare costs in asthma.

ABSTRACT: Asthma exacerbations contribute significantly to morbidity, mortality, and healthcare costs, with antibiotics commonly prescribed despite uncertain benefits and risks. This retrospective cohort study analyzed claim database between 2020 and 2022. Patients were categorized into extended (≥ 4 weeks) or limited (< 4 weeks) antibiotic exposure groups based on cumulative antibiotic use. We assessed the associations between prior antibiotic exposure and moderate-to-severe exacerbations, all-cause mortality, and total healthcare costs. We identified 549,425 adult asthma patients, classified into extended (25.2%) and limited (74.8%) antibiotic exposure groups. Extended antibiotic exposure was significantly associated with moderate-to-severe exacerbations (aOR = 1.25, 95% CI = 1.23-1.26) and nearly

SUBMITTER: Lee HW 

PROVIDER: S-EPMC12494924 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature