Dynamic immune dysregulation in severe mental illness: Exaggerated innate and attenuated adaptive immune responses following SARS-CoV-2 vaccination.

ABSTRACT:

Background

Immune dysregulation in severe mental illness (SMI) is usually characterised using static measurements. As such, how the immune system of SMI patients responds to real-world challenges remains largely unknown. Prior studies suggest that patients may exhibit an exaggerated innate and attenuated adaptive immune response, but in vivo studies are lacking.

Objectives

This study aimed to assess immune responses to SARS-CoV-2 vaccination in SMI patients compared to non-psychiatric controls (NPCs). We investigated post-vaccination changes in cytokine and antibody levels, their associations, and secondary measures including tryptophan-kynurenine pathway metabolites and psychiatric symptoms.

Methods

We collected blood samples of 72 SMI patients and 127 NPCs before an

SUBMITTER: Rietberg T 

PROVIDER: S-EPMC12494927 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature