Targeting chaperone-mediated autophagy to regulate osteoclast activity as a therapeutic strategy for osteoporosis.

ABSTRACT: Osteoporosis is an age-related bone metabolic disease characterized by a persistent bone mass decrease and bone structure destruction. Osteoclasts, important cells in the bone remodelling process, are closely associated with the onset and progression of osteoporosis; however, the regulatory mechanisms involved remain unclear. In this study, TFE3 cytoplasmic translocation inhibited LAMP2A expression in osteoclasts and precursors in elderly individuals with osteoporosis and the downregulation of LAMP2A expression mediated the attenuation of chaperone-mediated autophagy (CMA). This inhibition prevented intracellular CCR5 degradation, increased the osteoclast differentiation of osteoclast precursor cells, and enhanced the bone resorption activity of mature osteoclasts, leading to bone loss and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12494939 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature