LncRNA RMRP knockdown upregulates PD-1 expression in natural killer cells.

ABSTRACT: The role of long non-coding RNAs (lncRNAs) in Natural Killer (NK) cells is still an ongoing research question. LncRNAs are RNAs with a length of more than 200 nucleotides. While they do not code for functional proteins, they have many regulatory roles from transcriptional to post-translational mechanisms that can affect gene expression. On the other hand, NK cells are large, innate, granular immune cells that exert cytotoxic effects against virus-infected and malignant cells using various mechanisms of actions. In this study, we aimed to perform functional analysis of lncRNAs in NK cells. We focused on five lncRNAs: MALAT1, RMRP, LINC-PINT, GAS5, and LINC00299. Our findings revealed that the expressions of the five lncRNAs were downregulated in cultured NK cells and upon cytokine stimulati

SUBMITTER: Abouhegaziah S 

PROVIDER: S-EPMC12494946 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature