Cocklebur-inspired magnetic nanomotors for targeted thrombus therapy.

ABSTRACT: Nanomotors have come to the forefront as a powerful tool for thrombolysis. Attempts in this field tend to improve the structure and function of nanomotors for safe and efficient treatment. To address the problem of low utilization and high bleeding risk, herein, we present a magnetically-driven cocklebur-like nanomotor for efficient delivery of recombinant tissue plasminogen activator (rt-PA) to treat thrombus. Composed of Fe₃O₄ cores and spiked silicate shells, these nanomotors can rapidly respond to magnetic fields and adhere to the thrombus regardless of the blood flow impact. Besides, we use an H₂O₂-responsive ester to conjugate rt-PA to the nanomotors, releasing the medication only around the thrombus with abundant reactive oxygen species, t

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12495074 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature