Glutamate, Contextual Insensitivity, and Disorganized Speech in First-Episode Schizophrenia: A 7T Magnetic Resonance Spectroscopy Study.

ABSTRACT:

Background

In people with schizophrenia, formal thought disorder is a core symptom that emerges early and persists into chronic stages despite treatments. It manifests as disorganized speech and is often associated with poor long-term outcomes. A key feature of this disorganization is an impairment in the buildup and use of context provided by preceding words when choosing upcoming words. Recent work has shown that spoken words are less predictable based on global linguistic context in schizophrenia, but the neural basis of this remains unknown. Glutamate dysfunction in the anterior cingulate cortex has long been implicated in schizophrenia, but its connection to behavioral impairments remains unclear.

Methods

In this study, we investigated the relationship between linguisti

SUBMITTER: Wang YL 

PROVIDER: S-EPMC12495089 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature