Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis.

ABSTRACT:

Background

Clinical outcomes following the first episode of psychosis (FEP) are highly heterogeneous across patients. The identification of prognostic biomarkers would greatly facilitate personalized treatments. Patients with psychosis often display brainwide disruptions of interregional functional coupling (FC), with some being linked to symptom severity and remission. Thus, FC may have prognostic potential for people experiencing psychosis.

Methods

Fifty-five antipsychotic-naïve patients with FEP (51% female, ages 15-25 years) were randomized to receive either antipsychotic or placebo tablets for 6 months alongside psychosocial interventions. Functional magnetic resonance imaging was conducted at baseline and after 3 months to evaluate whether baseline FC or 3-month change

SUBMITTER: Pope IZ 

PROVIDER: S-EPMC12495094 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature