Body Composition and Kidney Outcomes: A Cohort Study of Rapid Kidney Function Decline and a Mendelian Randomization Analysis of CKD Incidence.

ABSTRACT:

Rationale & objective

Chronic kidney disease (CKD) is a global health issue, potentially arising from rapid kidney function decline (RKFD). Although body composition influences various metabolic disorders, its relationship with kidney outcomes remains unclear. This study aimed to investigate the impact of body composition on RKFD and CKD risk.

Study design

A cohort study assessed the relationship between body composition and RKFD. A 2-sample Mendelian randomization approach investigated genetic evidence linking body composition to CKD risk.

Setting & participants

In total, 229 adults aged 50-70 years with normal kidney function were recruited from Huadong Hospital in Shanghai, China.

Predictors

Body composition indicators include fat mass, lean mass, appendicul

SUBMITTER: Li K 

PROVIDER: S-EPMC12495164 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature