Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma.

ABSTRACT:

Abstract

Multiple myeloma (MM) is a hematological disease of the plasma cell that remains clinically challenging despite the development of novel therapies. Epigenetic alterations have been demonstrated to contribute to MM pathogenesis, yet comprehensive studies into the links between different epigenetic regulatory systems in myeloma progression and drug resistance, though clinically relevant, are largely lacking. G9a and the DNA methyltransferases (DNMTs) are epigenetic modifiers that exhibit increased activity in MM, correlating with poor prognosis. To investigate the partnership between G9a and DNMTs, we used a combinatorial treatment approach involving small-molecule inhibitors. In-depth molecular analysis of the histone H3 lysine dimethylation distribution, the DNA methylome

SUBMITTER: Nylund P 

PROVIDER: S-EPMC12495168 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature