A surgical therapy for Alzheimer's disease with lymphaticovenular anastomosis.

ABSTRACT:

Background

Deep cervical lymphaticovenular anastomosis (dcLVA) surgery is able to control aging-associated Alzheimer's disease in patients. However, the efficacy rate remains unknown.

Objective

This study is designed to test the surgery efficacy in the treatment of mild-to-moderate AD patients.

Methods

This is a single-center retrospective study of dcLVA treatment of mild-to-moderate AD for 3 months. A total of 41 patients received the surgery, in which lymph vessels and lymph nodes in the district III of cervical area were identified using indocyanine fluorescence dye. The afferent lymphatics of the obstructed lymph nodes were connected to the jugular vein to fix the lymphatic blockage under a fluorescent microscope. The efficacy rate was examined at 3-month post-sur

SUBMITTER: Ma X 

PROVIDER: S-EPMC12495200 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature