Management of biliary tract cancers in elderly patients: a French multicenter retrospective study (PRONOBIL-ACABi).

ABSTRACT:

Background

Biliary tract cancers (BTC) are often diagnosed after the age of 70, when comorbidities and compromised performance status (PS) are more prevalent.

Objectives

This study compared clinical and disease characteristics and outcomes in BTC patients aged ⩽70 and >70 years.

Design and methods

PRONOBIL-ACABI is a cohort study including 1256 BTC patients treated across 16 French centers from January 2003 to June 2021. We analyzed demographics, clinical characteristics, treatment modalities, molecular profiles, overall survival (OS) as the primary endpoint, and progression-free survival (PFS).

Results

Among the 1256 BTC patients (53% male; median age: 64.5), 31% were aged >70. Patients >70 exhibited poorer PS (PS ⩾2, 17% vs 8%; p < 0.0001), a higher ra

SUBMITTER: Valery M 

PROVIDER: S-EPMC12495211 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature