Efficacy of Endostar plus concurrent chemoradiotherapy in locally advanced cervical cancer: a multicenter, phase II randomized trial.

ABSTRACT:

Background

Cervical cancer remains the fourth most common malignant cancer in females and the fourth most common cause of mortality in women worldwide. Approximately 70% of new cases are diagnosed as locoregionally advanced cervical cancer (LACC), posing a significant threat to women's health. Concurrent chemoradiotherapy (CCRT) is the established standard treatment for LACC. However, more than 30% of patients still experience local recurrence and distant metastasis. Improving treatment outcomes for LACC is a critical global objective.

Objective

To investigate the safety and efficacy of adding Endostar to CCRT in patients with LACC.

Design

This is a multicenter, open-label, randomized, controlled, phase II trial.

Methods

A total of 120 patients were randomly al

SUBMITTER: Wu F 

PROVIDER: S-EPMC12495213 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature